Database : HANSEN Search on : INTERFERON TIPO II [Subject descriptor] References found : 63 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19534 Author: Manandhar, Rakesh; LeMaster, Joseph W; Butlin, C. Ruth; Brennan, Patrick J; Roche, Paul W. Title: Interferon-Gamma responses to candidate leprosy skin-test reagents detect exposure to leprosy in an endemic population. Source: Int. J. Lepr;68(1):40-48, Mar., 2000. tab, graf. Abstract: New tools for the detection of leprosy exposure in a community will be necessary for the eradication of leprosy. Candidate leprosy skin-test antigens derived from the fractionation of the leprosy bacillus into cytoplasmic and cell-wall proteins free of immuno-inhibitory mycobacterial lipoglycans and carbohydrates were used in an overnight blood test to determine whether exposure to leprosy can be detected by the production of the cytokine interferon gamma (IFN-gamma). Strong IFN-gamma responses were detected in leprosy contacts to both skin-test antigens compared with control subjects from the same endemic communities. There was little response in patients with tuberculosis. Responses were greatest in contacts with recent leprosy exposure. The implications of these findings for the application of these reagents in a field trial as skin tests to detect exposure to leprosy are discussed in light of the strong association between overnight IFN-gamma to PPD and the tuberculin skin-test responses previously reported. (AU)^ien. Descriptors: Interferon Tipo II/farmacol Interferon Tipo II/uso terap Hanseníase/genet Hanseníase/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n1/v68n1a06.pdf / en Location: BR191.1

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13890 Author: Sagaró Delgado, Bartolomé; Días de la Rocha, Arturo; Cortina Morales, Mery; Collazo, sonia; Pérez Alonso, Teresita; Días, María A; Ochoa, Concepción; Guillama, Elizabeth; Bello, Iraldo; Lópes Saura, Pedro. Title: Uso sistémico del interferón gamma en lepra lepromatosa. Source: Fontilles - Revista de Leprología;17(5):469-477, May.-Ago. 1990. tab. Abstract: La existencia de un defecto específico en la respuesta inmune mediada por células ha sido señalada en la lepra lepromatosa. Se sugiere la posibilidad de uq el interferon (IFN) gamma influya em el dominio del espectro inmunológico lepromatoso. Se hace un estudio para demostrar si el IFN gamma como coadyuvante de la terapéutica específica es capaz de transformar o modificar el efecto inmunológico en la lepra lepromatosa. Se seleccionarán 20 pacientes vírgenes de tratamiento o con menos de dos años de terapéutica específicas distribuidos de acuerdo a tabla aleatoria en dos grupos que reciben IFN gamma o placebo además de la quimioterapia especifica. Antes del tratamiento y al final del mismo se realizarán los siguientes estudios: histopatológico, inmunológico y bacteriológico. Se presenta comunicación preliminar de acuerdo a corte realizado en los dos pacientes que culminaron su estudio: uno tratado con IFN gamma y otro que recibió palcebo, siendo la respuesta notablemente superior en el primero desde los puntos de vista clínico, bacteriológico e inmunológico, llegando a negativizar la detección de bacilos. (AU). Descriptors: HANSENIASE VIRCHOWIANA/quimioter HANSENIASE VIRCHOWIANA/etiol INTERFERON TIPO II/admin Location: BR191.1

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Id: 13650 Author: Hernandez, M. O; Neves Junior, I; Sales, J. S; Carvalho, D. S; Sarno, E. N; Sampaio, E. P Title: Induction of apoptosis in monocytes by Mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha ..- Source: s.l; s.n; 2003. 9 p. graf. Abstract: A diverse range of infectious organisms, including mycobacteria, have been reported to induce cell death in vivo and in vitro. Although morphological features of apoptosis have been identified in leprosy lesions, it has not yet been determined whether Mycobacterium leprae modulates programmed cell death. For that purpose, peripheral blood mononuclear cells obtained from leprosy patients were stimulated with different concentrations of this pathogen. Following analysis by flow cytometry on 7AAD/CD14+ cells, it was observed that M. leprae induced apoptosis of monocyte-derived macrophages in a dose-dependent manner in both leprosy patients and healthy individuals, but still with lower efficiency as compared to M. tuberculosis. Expression of tumour necrosis factor-alpha (TNF-alpha), Bax-alpha, Bak mRNA and TNF-alpha protein was also detected in these cultures; in addition, an enhancement in the rate of apoptotic cells (and of TNF-alpha release) was noted when interferon-gamma was added to the wells. On the other hand, incubation of the cells with pentoxifylline impaired mycobacterium-induced cell death, the secretion of TNF-alpha, and gene expression in vitro. In addition, diminished bacterial entry decreased both TNF-alpha levels and the death of CD14+ cells, albeit to a different extent. When investigating leprosy reactions, an enhanced rate of spontaneous apoptosis was detected as compared to the unreactive lepromatous patients. The results demonstrated that M. leprae can lead to apoptosis of macrophages through a mechanism that could be at least partially related to the expression of pro-apoptotic members of the Bcl-2 protein family and of TNF-alpha. Moreover, while phagocytosis may be necessary, it seems not to be crucial to the induction of cell death by the mycobacteria. (AU). Descriptors: APOPTOSE/ef drogas APOPTOSE/imunol CELULAS CULTIVADAS REGULACAO DA EXPRESSÃO GÊNICA INTERFERON TIPO II/farmacol HANSENIASE/imunol PROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MONOCITOS/patol MYCOBACTERIUM LEPRAE/imunol PENTOXIFILINA/farmacol FAGOCITOSE/imunol PROTEINAS PROTO-ONCOGÊNICAS/genet FATOR DE NECROSE TUMORAL/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09128/s

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Id: 13429 Author: Nogueira, N; Kaplan, G; Levy, E; Sarno, E. N; Kushner, P; Granelli-Piperno, A; Vieira, L; Colomer Gould, V; Levis, W; Steinman, R Title: Defective gamma interferon production in leprosy ..- Source: s.l; s.n; December 01, 1983. 6 p. tab. Abstract: Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.(AU). Descriptors: HANSENIASE/imunol INTERFERON TIPO II/bios MYCOBACTERIUM LEPRAE/imunol ANTIGENOS DE BACTERIAS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01387/s

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Id: 12323 Author: Casanova, Jean-Laurent; Abel, Laurent Title: Genetic dissection of immunity to mycobacteria: the human model ..- Source: s.l; s.n; 2002. 40 p. ilus, tab. Descriptors: MICROBIOLOGIA AMBIENTAL IMUNIDADE SINDROMES DE DEFICIENCIA IMUNOLOGICA SINDROMES DE DEFICIENCIA IMUNOLOGICA SINDROMES DE DEFICIENCIA IMUNOLOGICA INTERFERON TIPO II INTERLEUCINA-12 MODELOS IMUNOLOGICOS MYCOBACTERIUM MYCOBACTERIUM MICOBACTERIOSE MICOBACTERIOSE MICOBACTERIOSE MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS VIRULENCIA Location: BR191.1; 08717/s

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Id: 12294 Author: Macfarlane, Anne; Mondragon-Gonzalez, Rafael; Vega-Lopez, Francisco; Wieles, Brigitte; Pena, Josefina de; Rodriguez, Obdulia; Torre, Raul Suarez y de la; Vries, Rene R. P. de; Ottenhoff, Tom H. M; Dockrell, Hazel M Title: Presence of human T-cell responses to the mycobacterium leprae 45-kilodalton antigen reflects infections with or exposure to M. leprae ..- Source: s.l; s.n; May 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS MARCADORES BIOLOGICOS INTERFERON TIPO II HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE LINFOCITOS T Location: BR191.1; 08672/s

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Id: 12291 Author: Little, David; Khanolkar-Young, Saroj; Coulthart, Anne; Suneetha, Sujai; Lockwood, Diana N. J Title: Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment ..- Source: s.l; s.n; May 2001. 5 p. ilus, tab, graf. Descriptors: IMUNOHISTOQUIMICA INTERFERON TIPO II INTERLEUCINA-12 HANSENIASE HANSENIASE HANSENIASE SINTASE DE OXIDO NITRICO PREDNISOLONA Location: BR191.1; 08686/s

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Id: 12288 Author: Adams, Linda B; Scollard, David M; Ray, Nashome A; Cooper, Andrea M; Frank, Anthony A; Orme, Ian M; Krahenbuhl, James L Title: The study of mycobacterium leprae infection in interferon-gamma gene - disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Source: s.l; s.n; 2002. 8 p. ilus, graf. Descriptors: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PELE PELE DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Limits: ANIMAL Location: BR191.1; 08655/s

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Id: 12281 Author: Cooper, Andrea M; Adams, Linda B; Dalton, Dyana K; Appelberg, Rui; Ehlers, Stefan Title: IFN-gamma and NO in mycobacterial disease: new jobs for old hands ..- Source: s.l; s.n; May 2002. 6 p. ilus. Descriptors: GRANULOMA GRANULOMA INTERFERON TIPO II HANSENIASE MACROFAGOS CAMUNDONGOS MODELOS IMUNOLOGICOS MICOBACTERIOSE MYCOBACTERIUM AVIUM MYCOBACTERIUM BOVIS OXIDO NITRICO SINTASE DE OXIDO NITRICO TUBERCULOSE PULMONAR TUBERCULOSE PULMONAR Limits: ESTUDO COMPARATIVO Location: BR191.1; 08649/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 12245 Author: Geluk, Annemieke; Van Meijgaarden, Krista E; Franken, Kees L. M. C; Subronto, Yanri W; Wieles, Brigitte; Arend, Sandra M; Sampaio, Elizabeth P; Boer, Tjitske de; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: Identification and characterization of the ESAT-6 homologue of mycobacterium leprae and T-cell cross-reactivity with mycobacterium tuberculosis ..- Source: s.l; s.n; May 2002. 5 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS REAÇOES CRUZADAS INTERFERON TIPO II HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TUBERCULOSE Location: BR191.1; 08648/s

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Id: 12240 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, T. H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the mycobacterium leprae 45-kD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR Células Cultivadas Limits: ESTUDO COMPARATIVO Location: BR191.1; 08643/s

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Id: 12234 Author: Ohyama, Hideki; Matsushita, Sho; Nishimura, Fusanori; Kato, Nahoko; Hatano, Kentaro; Takashiba, Shogo; Murayama, Yoji Title: T cell responses to major membrane protein II (MMP II) of mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy ..- Source: s.l; s.n; 2001. 8 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS ANTIGENOS HLA-DR INTERFERON TIPO II INTERLEUCINA-5 HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE LINFOCITOS T Location: BR191.1; 08636/s

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Id: 12103 Author: Machado, Paulo Title: Produção de citocinas por células mononucleares do sangue periférico na hanseníase ?- Source: Salvador; s.n; 1997. vii,55 p. ilus, tab, graf. Thesis: Present for Universidade Federal da Bahia. Faculdade de Medicina presented for the degree Mestre. Abstract: A hanseníase é uma doença espectral que apresenta grande variação no quadro clínico, diretamente relacionada com a resposta imune celular do hospedeiro dirigida contra os antígenos do Mycobacterium Leprae. Assim, no pólo tuberculóide, o quadro clínico de poucas lesões associa-se a uma baixa carga bacilar e à presença da resposta imune celular contra o bacilo de Hansen. No outro pólo da doença, a forma virchowiana, o quadro clínico de lesões disseminadas está associado a uma alta bacilífera e ausência de resposta imune celular. A produção de citocinas pelo sistema imune parece de fundamental importância na regulação da resposta imune humoral e celular, sendo por sua vez modulada por antígenos micobacterianos diversos. Portanto, as duas formas 'polares da hanseníase devem se diferenciar quanto ao perfil de produção de citocinas em resposta ao M. leprae, e difrentes antígenos micobacterianos devem modificar este perfil.(AU). Descriptors: Citocinas Imunologia HANSENIASE Interferon Tipo II Location: BR191.1; WC335.500, M119p

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Id: 11830 Author: Casanova, Jean-Laurent; Abel, Laurent Title: Genetic dissecation of immunity to mycobacteria: the human model ..- Source: s.l; s.n; 2002. 50 p. ilus, tab. Descriptors: MICROBIOLOGIA AMBIENTAL MYCOBACTERIUM MYCOBACTERIUM IMUNIDADE INTERFERON TIPO II MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS Location: BR191.1; 08548/s

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Id: 11759 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, Tom H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the Mycobacterium leprae 45-KD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08519/s

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Id: 11755 Author: Adams, Linda B; Scollard, David M; Ray, Nashone A; Cooper, Andrea M; Frank, Anthony A; Orne, Ian M; Krahenbuhl, James L Title: The study of Mycobacterium leprae infection in interferon-y gene-disrupted mice as a model to explore the immunopathologic spectrum of leprosy ..- Source: s.l; s.n; 2002. 8 p. ilus, graf. Descriptors: LINFOCITOS T CD4-POSITIVOS LINFOCITOS T CD8-POSITIVOS CITOCINAS MODELOS ANIMAIS DE DOENÇAS CITOMETRIA DE FLUXO PÉ PÉ DELEÇAO DE GENES IMUNOHISTOQUIMICA INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA MACROFAGOS PERITONEAIS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANIMAL LINFONODOS/IM Limits: ANIMAL Location: BR191.1; 08511/s

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Id: 11720 Author: Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C Title: Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect ..- Source: s.l; s.n; 2000. 9 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE ANTIGENOS CD56 CHAPERONINAS CITOTOXICIDADE IMUNOLOGICA SINERGISMO DE DROGAS SOROS IMUNES INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-4 INTERFASE LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES TRANSFORMAÇAO LINFOCITICA COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE LIGAÇAO PROTÉICA LINFOCITOS T CITOTOXICOS LINFOCITOS T CITOTOXICOS FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR FATOR DE NECROSE DE TUMOR Location: BR191.1; 07463/s

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Id: 11703 Author: Moraes, Milton O; Sarno, Euzenir N; Teles, Rosane M. B; Almeida, Alexandre S; Saraiva, Bruno C. C; Nery, José A. C; Sampaio, Elizabeth P Title: Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients ..- Source: s.l; s.n; 2000. 6 p. tab. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTIINFLAMATORIOS ANTIINFLAMATORIOS BIOPSIA CITOCINAS CITOCINAS ERITEMA NODOSO ERITEMA NODOSO EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-4 REAÇAO EM CADEIA POR POLIMERASE PELE PELE FATOR DE NECROSE DE TUMOR Location: BR191.1; 08424/s

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